Pharmaceutical Intermediates

Catering to the complexity and molecular diversity of modern pharmaceuticals requires an enormous amount of global coordination. Organizations around the world need to work together to supply everything from starting materials to advanced API intermediates for the production of both branded and generic drugs.

  • With a sizable global footprint and solid partnerships with pharmaceutical intermediates manufacturers, Shreem Lifesciences safely manages schedules, logistics, timelines, and international distribution.
  • Shreem Lifesciences understands that CMOs and innovators often have special standards for raw material and API intermediate quality, based on their capabilities and end-products.
  • With our breadth of offerings, excellent quality assurance, and premier customer service, Shreem Lifesciences optimizes your pharmaceutical intermediate supply chain and solve challenges along the way

Commercialized Intermediates

S.NoPRODUCT NAMECAS NoEND USE
14-Hydrazinobenzenesulfonamide hydrochloride17852-52-7Celecoxib
24-Methyl acetophenone122-00-9Celecoxib
34-Bromo-1-chloro-2-(4-ethoxybenzyl)benzene461432-23-5Dapagliflozin
4(5-Bromo-2-chlorophenyl)(4-ethoxyphenyl)methanone461432-22-4Dapagliflozin
55-Bromo-2-chlorobenzoic acid21739-92-4Dapagliflozin
6(5-Bromo-2-chlorophenyl)(4-fluorophenyl)methanone915095-85-1Empagliflozin
7(3S)-3-[4-[(5-Bromo-2-chlorophenyl)methyl]phenoxy]tetrahydrofuran915095-89-5Empagliflozin
84-Fluorophenyl-5’-oxobutyric Acid149437-76-3Ezetimibe
9(4S)-4-Phenyl-3-[5-(4-fluorophenyl)-5-oxopentanoyl]-1,3-oxazolidin-2-one;189028-93-1Ezetimibe
104-[[(4-Fluorophenyl)imino]methyl]phenol3382-63-6Ezetimibe
11(5-Methyl-2-oxo-1,3-dioxol-4-yl)methyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate144690-92-6Olmesartan
124-(4-Aminophenyl)-3-morpholinone438056-69-0Rivaroxaban
135-Chlorothiophene-2-carboxylic acid24065-33-6Rivaroxaban
14(S)-2-(Oxiran-2-ylmethyl)-1H-isoindole-1,3(2H)-dione161596-47-0Rivaroxaban
15(R)-2-(2-Hydroxy-3-((4-(3-oxomorpholino)phenyl)amino) propyl)isoindoline-1,3-dione446292-07-5Rivaroxaban
16(S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl) oxazolidin-5-yl)methyl)isoindoline-1,3-dione446292-08-6Rivaroxaban
17(S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one hydrochloride898543-06-1Rivaroxaban
184-Nitrophenyl 5-chlorothiophene-2-carboxylate1450877-56-1Rivaroxaban
19(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride1062580-52-2Tofacitinib
204-Chloropyrrolo[2,3-d]pyrimidine 3680-69-1Tofacitinib
218-Bromo-3-methyl-7-(2-butynyl)-xanthine666816-98-4Linagliptin
222-(Chloromethyl)-4-methylquinazoline109113-72-6Linagliptin
238-Bromo-3-methylxanthine93703-24-3Linagliptin
248-Bromo-7-(2-butyn-1-yl)-3,7-dihydro-3-methyl-1-[(4-methyl-2-quinazolinyl)methyl]-1H-purine-2,6-dione853029-57-9Linagliptin
253-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 762240-92-6Sitagliptin
261-(3-(Trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butane-1,3-dione 764667-65-4Sitagliptin
27Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate769195-26-8Sitagliptin
28(Z)-Methyl 3-amino-4-(2,4,5-trifluorophenyl)but-2-enoate881995-70-6Sitagliptin
292,2-Dimethyl-1,3-dioxane-4,6-dione (Meldrum's acid)2033-24-1Sitagliptin
30(S)-1-(4-Phenyl-1H-imidazol-2-yl)ethanamine864825-23-0Eluxadoline
313-Quinuclidinone Hydrochloride1193-65-3Solifenacin succinate
32N-(Tosylmethyl)formamide36635-56-0BEMPEDOIC ACID
33Tosylmethyl isocyanide (1-(isocyanatomethylsulfonyl)-4-methylbenzene.)10564-55-3.BEMPEDOIC ACID
342,2,14, 14-Tetramethyl-8-oxopentadecanedioic acid413624-71-2BEMPEDOIC ACID
35Tert-butyl 4-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate953071-73-3Bilastine
363-aminoadamantan-1-ol 702-82-9Vildagliptin
37 1-(2-Chloroacetyl)pyrrolidine-2-carbonitrile 274901-37-0Vildagliptin
382,4-Dihydro-4-[4-[4-(4-hydroxyphenyl)-1-piperazinyl]phenyl]-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one106461-41-0Itraconazole
39cis-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-methanol methanesulfonate67914-86-7Itraconazole
4010-Methoxy-2,2'-iminostilbene4698-11-7Oxycarbazapine
4110,11-Dihydro-5H-dibenzo[b,f]azepine494-19-9Oxycarbazapine

Intermediates in Pilot Scale

S.NoPRODUCT NAMECAS NoEND USE
12,6-Dichloro-3,5-dimethoxyaniline872509-56-3Infigratinib
26-Chloro-N-methylpyrimidin-4-amine65766-32-7Infigratinib
33-(5-Hydroxy-2-pyrimidinyl)benzoic acid (3-(5-Hydroxypyrimidin-2-yl)benzoic acid)1092568-86-9Tepotinib
43-(5-Methyl-1,2,4-oxadiazol-3-yl)benzoic acid264264-32-6Tepotinib
5Methanaminium, 1-[[2-(dimethylamino)-1-[(dimethyliminio)methyl]ethenyl]amino]-N,N-dimethyl-, hexafluorophosphate(1-) (1:2) 1161737-41-2Tepotinib
6IntermediatesZanubrutinib

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